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Saturday, April 6, 2013
Cats compete in Hallmark Channel's 'Kitten Bowl'
NEW YORK (AP) ? The rivalry on Super Bowl Sunday is already shaping up as a battle between puppies and kittens.
Hallmark Channel says it's introducing an annual "Kitten Bowl" on Feb. 2. It's a three-hour showcase of feline agility, but the network says any form of cuteness is key to the game.
Cat contenders will be recruited from animal shelters. The prize will be a loving home for these orphans.
"Kitten Bowl," produced in partnership with the American Humane Association, will be vying for viewers with Animal Planet's 10th annual "Puppy Bowl," which features its own "Kitty Half-Time Show."
Hallmark's "Kitten Bowl" will air at 12 noon Eastern time, then encore twice immediately after.
Of course, viewers who don't care about puppies or kitties won't be forgotten. There'll be football on another channel.
Source: http://news.yahoo.com/cats-compete-hallmark-channels-kitten-bowl-162048728.html
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Roger Ebert Dead At Age 70
Film critic's death comes just two days after announcing his cancer had returned.
By Kevin P. Sullivan
Roger Ebert and Gene Siskel in 1994
Photo: Ron Galella, Ltd./ WireImage
Source: http://www.mtv.com/news/articles/1705016/roger-ebert-dead.jhtml
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Thursday, April 4, 2013
CHART OF THE DAY: Time Spent On Facebook - Business Insider
There is, and probably always will be, a story floating the ether that Facebook is getting smoked by up and coming rivals like SnapChat, Whatsapp, or Twitter.
While those services are certainly popular, they're not hurting Facebook, according to comScore data analyzed by J.P. Morgan analyst Doug Anmuth. Anmuth notes that Facebook's share of total mobile minutes continues to rise, while share of time spent on those other sites remains relatively flat.
Though, as Peter Kafka at All Things D notes, Anmuth isn't looking at demographic data. Most of the concern about Facebook is that it's lost its edge with teens. If that's true, it will show up in the data soon enough.
Source: http://www.businessinsider.com/chart-of-the-day-time-spent-on-facebook-2013-4
Arizona tribe seeks artifacts up for auction
FLAGSTAFF, Ariz. (AP) ? An Arizona tribe is asking a Paris auction house to cancel its upcoming sale of dozens of items central to the tribe's religious practices and return them to their original homes in the American Southwest.
Neret-Minet Tessier & Sarrou describes the collection on its website as katsina masks of the Hopi Indians of Arizona. They are scheduled to be auctioned April 12, with some expected to garner tens of thousands of dollars each.
To the Hopis, they are living beings called katsina friends that emerge from the earth and sky to connect people to the spiritual world and their ancestors. Every member of the Hopi Tribe gets initiated into the Katsina society as a rite of passage.
Leigh Kuwanwisiwma, director of the tribe's cultural preservation office, said the religious items have no commercial value and should be in the hands of the American Indian tribes from which they were taken, including the pueblos of Jemez, Acoma and Zuni in New Mexico. The sale of such items isn't extraordinary, but the size of the collection to be auctioned in Paris and the age of the items is, he said.
The majority of the 70 katsina friends are labeled as Hopi and date back to the late 19th century and early 20th century. Kuwanwisiwma said they likely were collected from the Hopi in the 1930s and 1940s when there was documented evidence of a French citizen on the northern Arizona reservation.
"A lot of these objects were collected under suspicious conditions," he said. "You had such a huge competition by museums to collect artifacts from tribal reservations, and Hopi was no exception."
Acoma Pueblo said Wednesday that it would look into whether a piece labeled as originating from Acoma is authentic and would support any efforts to repatriate American Indian artifacts.
The Native American Graves Protection and Repatriation Act gives federally recognized American Indian tribes a way to reclaim funerary objects and ceremonial items from federal agencies and museums in the United States. Sherry Hutt, the program manager for the national NAGPRA office under the U.S. Department of the Interior said the law doesn't always apply to items held internationally.
"Did it leave at the time by gift or was it removed without permission? What were the rules at the time?" she said. "Once you know that, you may or may not have an application of NAGPRA, you may or may not have statues that apply to cultural resources or other remedies, generally."
An email sent to Neret-Minet Tessier & Sarrou on Tuesday was not returned, and the auction house declined immediate comment when contacted by a reporter on Wednesday. The press release announcing the auction said the items were collected by a "connoisseur with peerless taste," who had lived in the United States for more than 30 years and had attended katsina dances at the Hopi villages but doesn't say how.
Jose Viarreal, editor of the website artdaily.org, published the news release and said he received calls afterward from Hopis furious about the sale. He said he contacted the auction house and was told the items were obtained legally.
"I think this is going to go through as planned," he said.
Kuwanwisiwma said no Hopi has authority to sell or transfer such items because they are considered cultural patrimony, and no one other than a Hopi tribal member should possess them. Things haven't always worked out that way.
The Heard Museum in Phoenix is backing the Hopi Tribe's effort to recover the items and said it was hopeful the U.N. Declaration on the Rights of Indigenous People could be used as leverage. France was among the first to sign the declaration that says indigenous people have the right to repatriation of their human remains, ceremonial objects and cultural patrimony.
The auction house cited a book written by the founder of the Museum of Northern Arizona in its description of the katsinas, which Hopi artists commonly depict in carved, wooden figures and sell. The museum's director, Robert Breunig, appealed to the sense of decency and humanity in asking that the auction be called off.
"To be displayed disembodied in your catalog and on the Internet is sacrilegious and offensive," he wrote in a letter to the auction house. "If one claims to value these katsina friends as 'works of art,' one must also respect the people who made them and the native traditions that govern their use."
If returned, Kuwanwisiwma said the items will be placed in the care of the head katsina priest. The tribe would not bid on the objects otherwise, he said.
"Culturally we made it clear that there's no price tag on our ceremonial and religious objects," he said. "That's pretty much out of the question."
___
Associated Press Writer Lori Hinnant in Paris contributed to this report.
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Wednesday, April 3, 2013
Crucial step in human DNA replication observed for the first time
Tuesday, April 2, 2013
For the first time, an elusive step in the process of human DNA replication has been demystified by scientists at Penn State University. According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human DNA replication is performed." The results of the research will be published in the journal eLife on 2 April 2013.
Part of the DNA replication process -- in humans and in other life forms -- involves loading of molecular structures called sliding clamps onto DNA. This crucial step in DNA replication had remained somewhat mysterious and had not been well studied in human DNA replication. Mark Hedglin, a post-doctoral researcher in Penn State's Department of Chemistry and a member of Benkovic's team, explained that the sliding clamp is a ring-shaped protein that acts to encircle the DNA strand, latching around it like a watch band. The sliding clamp then serves to anchor special enzymes called polymerases to the DNA, ensuring efficient copying of the genetic material. "Without a sliding clamp, polymerases can copy very few bases -- the molecular 'letters' that make up the code of DNA -- at a time. But the clamp helps the polymerase to stay in place, allowing it to copy thousands of bases before being removed from the strand of DNA," Hedglin said.
Hedglin explained that, due to the closed circular structure of sliding clamps, another necessary step in DNA replication is the presence of a "clamp loader," which acts to latch and unlatch the sliding clamps at key stages during the process. "The big unknown has always been how the sliding clamp and the clamp loader interact and the timing of latching and unlatching of the clamp from the DNA," said Hedglin. "We know that polymerases and clamp loaders can't bind the sliding clamp at the same time, so the hypothesis was that clamp loaders latched sliding clamps onto DNA, then left for some time during DNA replication, returning only to unlatch the clamps after the polymerase left so they could be recycled for further use."
To test this hypothesis, the team of researchers used a method called F?rster resonance energy transfer (FRET), a technique of attaching fluorescent "tags" to human proteins and sections of DNA in order to monitor the interactions between them. "With these tags in place, we then observed the formation of holoenzymes -- the active form of the polymerase involved in DNA replication, which consists of the polymerase itself along with any accessory factors that optimize its activity," Hedglin said. "We found that whenever a sliding clamp is loaded onto a DNA template in the absence of polymerase, the clamp loader quickly removed the clamp so that free clamps did not build up on the DNA. However, whenever a polymerase was present, it captured the sliding clamp and the clamp loader then dissociated from the DNA strand."
The team members also found that, during the moments when both the clamp loader and the clamp were bound to the DNA, they were not intimately engaged with each other. Rather, the clamp loader released the closed clamp onto the DNA, allowing an opportunity for the polymerase to capture the clamp, completing the assembly of the holoenzyme. Subsequently, the clamp loader dissociated from DNA. "Our research demonstrates that the DNA polymerase holoenzyme in humans consists of only a clamp and a DNA polymerase. The clamp loader is not part of it. It disengages from the DNA after the polymerase binds the clamp," Hedglin added.
Benkovic noted that this mechanism provides a means for the cell to recycle scarce clamps when they are not in use for productive replication.
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Penn State: http://live.psu.edu
Thanks to Penn State for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/127551/Crucial_step_in_human_DNA_replication_observed_for_the_first_time
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Tesla electric car, bashed by Romney, now showing profit, paid back Obama admin. loan 5 yrs early (Americablog)
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