Women under 60 with diabetes at much greater risk for heart disease

PUBLIC RELEASE DATE:

31-Oct-2013

[


| E-mail

]


Share

Contact: Patrick Smith
psmith88@jhmi.edu
410-955-8242
Johns Hopkins Medicine

Results of a Johns Hopkins study published today in the journal Diabetes Care found that young and middle-aged women with type 2 diabetes are at much greater risk of coronary artery disease than previously believed.

Generally, women under 60 are at far less risk for coronary artery disease than men of the same age. But among women of that age who have diabetes, their risk of heart disease increases by up to four times, making it roughly equal to men's risk of this same form of heart disease.

"Our findings suggest that we need to work harder to prevent heart disease in women under 60 who have diabetes," says Rita Rastogi Kalyani, M.D., M.H.S., endocrinologist at the Johns Hopkins University School of Medicine and lead study author. "This study tells us that women of any age who have diabetes are at a high risk for coronary artery disease."

While men generally have a higher incidence of heart disease than women, the study found that diabetes had little or no effect on men's heart disease risk.
Kalyani said the new study is believed to be the first to focus specifically on gender differences in coronary artery disease among younger and middle-aged people with diabetes.

For the research, she and her colleagues analyzed data from more than 10,000 participants in three widely regarded studies: the GeneSTAR Research Program, the Multi-Ethnic Study of Atherosclerosis and the National Health and Nutrition Examination Survey (NHANES) III. None of the participants had a history of heart disease. All three studies yielded similar gender differences in rates of diabetes and the risk of developing heart disease.

"Our study adds to growing evidence that gender differences exist in the risk of coronary artery disease brought on by diabetes," Kalyani says.

Interestingly, in both women and men, these findings were unrelated to differences in obesity and other traditional cardiovascular risk factors such as high blood pressure, cholesterol and smoking.

Kalyani and her colleagues offer several possible explanations for the increased risk. There may be distinct genetic and hormonal factors related to the development of heart disease by gender. Differences in adherence to heart-healthy lifestyle behaviors, compliance and treatment of cardiovascular treatments between genders are also possible but need to be further investigated, Kalyani says. Also, the relationship of diabetes duration and glucose control to risk of heart disease remains unclear.

###

In addition to Kalyani, the study's authors are Mario Lazo, M.D.; Pamelo Ouyang, M.B.B.S.; Karinne Chevalier, M.S.; Frederick Brancati, M.D., M.H.S.; Diane Becker, Sc.D., M.P.H.; and Dhananjay Vaidya, Ph.D., M.P.H., of the Johns Hopkins University School of Medicine, as well as Evrim Turkbey, M.D., of Radiology and Imaging Sciences at the National Institutes of Health Clinical Center.

About Johns Hopkins Medicine

Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is a $6.7 billion integrated global health enterprise and one of the leading academic health care systems in the United States. JHM unites physicians and scientists of the Johns Hopkins University School of Medicine with the organizations, health professionals and facilities of The Johns Hopkins Hospital and Health System. JHM's vision, "Together, we will deliver the promise of medicine," is supported by its mission to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care. Diverse and inclusive, JHM educates medical students, scientists, health care professionals and the public; conducts biomedical research; and provides patient-centered medicine to prevent, diagnose and treat human illness. JHM operates six academic and community hospitals, four suburban health care and surgery centers, and more than 35 Johns Hopkins Community Physicians sites. The Johns Hopkins Hospital, opened in 1889, was ranked number one in the nation for 21 years in a row by U.S. News & World Report. For more information about Johns Hopkins Medicine, its research, education and clinical programs, and for the latest health, science and research news, visit http://www.hopkinsmedicine.org.

Media Contacts: Patrick Smith

410-955-8242; psmith88@jhmi.edu or

Helen Jones

410-502-9422; hjones49@jhmi.edu

---

[


| E-mail


Share

]

 

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

PUBLIC RELEASE DATE:

31-Oct-2013

[


| E-mail

]


Share

Contact: Patrick Smith
psmith88@jhmi.edu
410-955-8242
Johns Hopkins Medicine

Results of a Johns Hopkins study published today in the journal Diabetes Care found that young and middle-aged women with type 2 diabetes are at much greater risk of coronary artery disease than previously believed.

Generally, women under 60 are at far less risk for coronary artery disease than men of the same age. But among women of that age who have diabetes, their risk of heart disease increases by up to four times, making it roughly equal to men's risk of this same form of heart disease.

"Our findings suggest that we need to work harder to prevent heart disease in women under 60 who have diabetes," says Rita Rastogi Kalyani, M.D., M.H.S., endocrinologist at the Johns Hopkins University School of Medicine and lead study author. "This study tells us that women of any age who have diabetes are at a high risk for coronary artery disease."

While men generally have a higher incidence of heart disease than women, the study found that diabetes had little or no effect on men's heart disease risk.
Kalyani said the new study is believed to be the first to focus specifically on gender differences in coronary artery disease among younger and middle-aged people with diabetes.

For the research, she and her colleagues analyzed data from more than 10,000 participants in three widely regarded studies: the GeneSTAR Research Program, the Multi-Ethnic Study of Atherosclerosis and the National Health and Nutrition Examination Survey (NHANES) III. None of the participants had a history of heart disease. All three studies yielded similar gender differences in rates of diabetes and the risk of developing heart disease.

"Our study adds to growing evidence that gender differences exist in the risk of coronary artery disease brought on by diabetes," Kalyani says.

Interestingly, in both women and men, these findings were unrelated to differences in obesity and other traditional cardiovascular risk factors such as high blood pressure, cholesterol and smoking.

Kalyani and her colleagues offer several possible explanations for the increased risk. There may be distinct genetic and hormonal factors related to the development of heart disease by gender. Differences in adherence to heart-healthy lifestyle behaviors, compliance and treatment of cardiovascular treatments between genders are also possible but need to be further investigated, Kalyani says. Also, the relationship of diabetes duration and glucose control to risk of heart disease remains unclear.

###

In addition to Kalyani, the study's authors are Mario Lazo, M.D.; Pamelo Ouyang, M.B.B.S.; Karinne Chevalier, M.S.; Frederick Brancati, M.D., M.H.S.; Diane Becker, Sc.D., M.P.H.; and Dhananjay Vaidya, Ph.D., M.P.H., of the Johns Hopkins University School of Medicine, as well as Evrim Turkbey, M.D., of Radiology and Imaging Sciences at the National Institutes of Health Clinical Center.

About Johns Hopkins Medicine

Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is a $6.7 billion integrated global health enterprise and one of the leading academic health care systems in the United States. JHM unites physicians and scientists of the Johns Hopkins University School of Medicine with the organizations, health professionals and facilities of The Johns Hopkins Hospital and Health System. JHM's vision, "Together, we will deliver the promise of medicine," is supported by its mission to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care. Diverse and inclusive, JHM educates medical students, scientists, health care professionals and the public; conducts biomedical research; and provides patient-centered medicine to prevent, diagnose and treat human illness. JHM operates six academic and community hospitals, four suburban health care and surgery centers, and more than 35 Johns Hopkins Community Physicians sites. The Johns Hopkins Hospital, opened in 1889, was ranked number one in the nation for 21 years in a row by U.S. News & World Report. For more information about Johns Hopkins Medicine, its research, education and clinical programs, and for the latest health, science and research news, visit http://www.hopkinsmedicine.org.

Media Contacts: Patrick Smith

410-955-8242; psmith88@jhmi.edu or

Helen Jones

410-502-9422; hjones49@jhmi.edu

---

[


| E-mail


Share

]

 

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-10/jhm-wu6103113.php
Similar Articles: Bitstrips   Tom Clancy   Robinson Cano   Brant Daugherty   futurama  

Nexus 5 bumper case and QuickCover listed as 'coming soon' on Play store

Sure, it's got a protective Gorilla Glass 3 coating, but there's only one way to really protect that new Nexus 5: cases. If you're breathlessly refreshing the Play store for a shot at ordering Google's new handset, you may want to check out the associated bumper case (available in black, grey, red ...

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/L03uTx-7hh8/
Similar Articles: silk road   drew brees   Roosevelt Field Mall   auburn football   Madden 25  

Do We Have a Legal Right to Light?

With supertall towers popping up along Central Park's southern edge like wildly expensive luxury mushrooms, Manhattan's largest park is about to be cast into shadow—some as long as half a mile. The real estate boom is stirring up a debate: Do we have a "right to light"?

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/yQ8FN_dI3Gg/do-we-have-a-legal-right-to-light-1455302177
Tags: revenge   south park   House of Cards   CJ Spiller   9/11 Pictures  

HTC: Android 4.4 KitKat coming to the One within 90 days, Google Play edition within 15 days

Now that we know which of Google's Nexus devices will be eligible for an update to Android 4.4 KitKat, other manufacturers are starting to speak up about their rollout plans as well. Jason Mackenzie, president of HTC America, confirmed to us in an interview that the company is going to aggressively push out the latest version of Android to the HTC One. The Google Play edition will be updated within the next 15 days, the Developer edition and unlocked versions will get it within 30 days, and the remaining SKUs in North America (including all carrier variants) will have it in 90 days or less. With the exception of the Google Play edition, HTC plans to keep its signature Sense UI at version 5.5 (which has been available on global devices running Android 4.3); and although Mackenzie couldn't go into details on how the new KitKat features will be implented in Sense, we expect to see plenty of them make an appearance in the update in some way.

HTC is still working on a rollout plan for the other devices in its portfolio, such as the One max and One mini, but Mackenzie assures us that the company will have a statement concerning those other phones in the near future. He also reiterated HTC's commitment to rapidly pushing out updates, telling us that "we're not going to [roll out updates] in a lazy fashion. We're going to make it a priority to have every dot release out on the One within 90 days."

Since Mackenzie spoke to us on behalf of the company's North American branch, we're still awaiting word on HTC's plans for its global devices. Given the fact that US operators are set to push out updates in the next 90 days, we'd be surprised if it doesn't arrive sooner on One units around the world.

Source: http://www.engadget.com/2013/10/31/htc-one-android-kitkat/?ncid=rss_truncated
Similar Articles: Battlefield 4 beta   college football  

Turning The Page On Illiteracy, Adults Go Back To Class

This is the first report of a four-part series on adult education.

The national debate around education usually focuses on children in school. But there are 30 million adults in the U.S. who have trouble with basic literacy — they struggle to read a menu, a pay stub or a bus schedule.

It also means it's difficult for them to get and hold onto the most basic jobs.

Tens of thousands of other adult learners are slowly and painstakingly trying to fill in the gaps of their rudimentary schooling. The long shadow of their unfinished education still follows them every day.

Learning Which Route To Take

Shirley Ashley, 55, never learned how to read. With classes, she is finally able to read her own bills.

Kavitha Cardoza/WAMU

Shirley Ashley, 55, never learned how to read. With classes, she is finally able to read her own bills.

Kavitha Cardoza/WAMU

Shirley Ashley flips through a folder of certificates she's received in her adult education class. She stops at one that says "Top Performer," points to the words and starts reading.

"I know this is 'top' something, that means I'm doing good," she says.

The word "performer" is still a jumble of letters because Ashley, at 55, never learned how to read. In school she was always in classes for students with learning disabilities, but Ashley says she wasn't learning anything.

"I felt as though they just passed me just to get me out of school," she says.

In the seventh grade, after one teacher told her, "Whether you learn to read or not, I still get paid," Ashley decided to drop out.

She learned how to give her mother medicine based on the colors of the bottles. To hide the fact she was illiterate, Ashley memorized Bible verses so no one at her church suspected. And she limited her travel to a familiar route.

"I couldn't read the name of the bus, but I learned that the left-hand side of the street would take me downtown and the right-hand side of the street was going to bring me back home," she says.

Ashley's inability to read has made it hard to find a job. She's also seen those closest to her take advantage of her illiteracy, especially when it came to money.

"I would have to pay them, my family members, to come over my house to do a money order," she says. "Sometimes I give them $25, sometimes I give them $30."

Ashley's attended classes at a nonprofit literacy center on and off for about eight years. She initially tested at the kindergarten level; she's now reading at the second-grade level.

"When my gas bill come to my house I'm learning how to read where it says 'pay by July 17th.' That makes me feel awesome," she says.

Getting To The Next Level

Ashley is at the "low end" of the literacy spectrum. Jason White, another adult learner is a little further along.

Marilyn Block tutors Jason White during a one-on-one session that is part of the Literacy Council of Montgomery County at a local library.

Kavitha Cardoza/WAMU

White is 35 and grew up in Louisiana. He dropped out in the 11th grade after years of sitting idle in a special education class. White found ways to cover up his reading struggles, from pretending he's forgotten his reading glasses to relying on computer's "auto-complete" function — even when he was out with friends.

"Say if you're at dinner with five people and you can't make out or read what's on the menu, someone says they're going to have the salmon filet, you say, 'Well I'll have the salmon filet,' " White says.

He works as a construction worker, and in a sense he's lucky. Adults who dropped out of school are more than twice as likely to be unemployed as high school graduates. For those who do get hired, it often means low-end jobs with no hope of advancing. In tough times, they're often the first ones laid off.

For White, not being able to read means his career has stalled. To advance, he needs a contractor's license, and he hopes he'll be able to pass the exam next month.

"I'm very handy, and we do terrific work, but I'm technically not a contractor until I pass that exam," he says. "So it's, it's a little nerve-wracking, you know?"

White has spent the past two years learning to read with a tutor. Now, he can write his own checks and has just finished reading his first novel. He marvels that he can now read street signs.

"If we're driving somewhere, I can't help but read every sign we pass," he says. "It's like a different world."

Source: http://www.npr.org/2013/10/31/241862699/turning-the-page-on-illiteracy-adults-go-back-to-class?ft=1&f=1013
Similar Articles: oarfish   Windows 8.1   banksy   Roosevelt Field Mall   aaliyah  

Cloudera pitches Hadoop for everything. Really?

When you have a big enough hammer, everything begins to look like the same kind of nail.

That's one of the potential problems with Hadoop 2.0, the greatly reworked big data processing framework that's been at the center of a whole storm of developer and end user interest. Cloudera in particular has plans to make it into a hammer for all kinds of nails.

There's no question that Hadoop 2.0 is a major leap over its predecessor. Instead of being a mere batch data processing framework for MapReduce jobs (limited, boring), it's now turned into a general framework for deploying applications across a multi-node system, with MapReduce just being one of the many possible things that can be run across those nodes (flexible, exciting).

Cloudera's clearly excited by the possibilities inherent in such an arrangement. During a keynote presentation at the O'Reilly Strata-Hadoop World conference in New York City this past Tuesday, the company described an "enterprise data hub" powered by Hadoop, one where all manner of data could be funneled in, processed in place, and extracted as needed.

Sounds great, but how feasible is it? Especially given Hadoop's status as the shiny new big data toy on the block? Such a hub may be a long way off for any company that's late to the big data party and has only just now found a place forits  multi-mega-terabyte data farms to live. Turning those "silos" (as Cloudera refers to legacy data repositories, with a near-audible sniff) into Hadoop installations isn't trivial.

The single biggest obstacle to making all that happen isn't Hadoop itself, although that's still a fairly major obstacle. In talking with vendors and users alike at Strata-Hadoop, it's clear Hadoop is still seen on all sides as a bucket of parts that needs major lifting and welding to be fully useful.

The most fruitful uses of Hadoop have been through the third parties that turn it into a ready-to-deploy product -- not just Cloudera or its quasi-rival Hortonworks, but cloud providers like Microsoft (a major Hortonworks partner), Amazon, SoftLayer, Rackspace, and just about every other name-brand cloud outfit. And few of them have yet to offer the kinds of really high-level abstraction we associate with powerful software tools, where the likes of Puppet or Python scripting are options rather than requirements.

The sheer number of moving parts and pointy edges that pop up out of Hadoop, even for smaller deployments, is still intimidating. A panel given by Dan McClary (principle product manager, Oracle) about Oracle building Hadoop appliances shed a lot of light on how much blood has to be shed, even by the likes of Oracle, to make Hadoop into a deliverable product. McClary was fairly sure over time Hadoop's rough edges would get sanded down by back-pressure from the community and vendors alike, but that time had definitely not arrived yet.

But the single biggest obstacle remains moving apps into Hadoop. The new infrastructure within Hadoop for applications, YARN, is far more open-ended than before, but it isn't trivial to rewrite an application to run there. It's not impossible there could be jury-rigs to accelerate that process -- e.g., some kind of virtualization wrapper that would allow apps to be arbitrarily shoehorned into the framework -- but that's not trivial work either.

Small wonder, then, that a great deal of work right now is being done to make Hadoop play well with existing apps -- connectors, data funnels, and the like. Very little of the discussion I encountered focused on moving existing apps into Hadoop, although few disagreed that it would happen eventually; most of it revolved around taking one's existing analytics and connecting them to Hadoop. There are, I imagine, far more people who want to do that than there are people who want to scrap everything and start over.

That said, the sheer level of bustle at the O'Reilly conference was a tipoff as to how soon that might happen. By this time next year, when the conference moves to the far-larger Javits Convention Center in Manhattan, some of Cloudera's pronouncements may seem a little less wildly optimistic. But until then, the trend right now is toward using Hadoop as a complement to existing big-data systems, not as a forklift upgrade for them.

This story, "Cloudera pitches Hadoop for everything. Really?," was originally published at InfoWorld.com. Get the first word on what the important tech news really means with the InfoWorld Tech Watch blog. For the latest developments in business technology news, follow InfoWorld.com on Twitter.

Source: http://www.infoworld.com/t/hadoop/cloudera-pitches-hadoop-everything-really-229879?source=rss_infoworld_top_stories_
Similar Articles: Giraffe Riddle Answer   Cricinfo   nytimes   Laura Prepon   new iphone  

A Beautiful Illustration of the Evolution of Audio Equipment

A lot's changed in the world of audio over the last 170 years. Gone are the days of cranking a handle to make noise, replaced instead by silicon and circuity to pump out digital tunes. This beautiful illustration walks you through how and when those changes happened.

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/GiORV61A4wU/a-beautiful-illustration-of-the-evolution-of-audio-equi-1455842455
Similar Articles: arian foster   dexter   Gta V Cheats   harry potter   monday night football  

We've Finally Figured Out Why Hot Water Freezes Faster Than Cold

For centuries, scientists have puzzled over a counter-intutive observation: hot water, for some reason, seems to freeze faster than cold. Fortunately, now a team of physicists has worked out why it happens.

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/kXLgcRBa8K4/weve-finally-figured-out-why-hot-water-freezes-faster-1455906029
Category: Sons Of Anarchy Season 6   lsu football