![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 31-Jan-2012[ | E-mail |
Share ] Contact: Michael Seele
mseele@bu.edu
617-353-9766
Boston University College of Engineering
BOSTON (1-31-12) -- Long duration, controllable drug delivery is of wide interest to medical researchers and clinicians, particularly those seeking to improve treatment for patients with chronic pain or to prevent cancer recurrence after surgery. Now a team of researchers led by Boston University Biomedical Engineer and Chemist Mark Grinstaff has developed a unique material and drug delivery mechanism that could pave the way for implants that release a drug at a designated rate for months.
The system consists of a biocompatible, highly porous, three-dimensional polymer material containing a selected drug and a volume of air that slows infiltration from surrounding water. As water seeps into the material, it displaces the air, gradually releasing the drug.
"The idea was to create a 3D material that has polymer fibers throughout and air trapped within," said Grinstaff, who developed the material in conjunction with BU biomedical engineering PhD student Stefan Yohe and Dr. Yolanda Colson, a Brigham and Women's Hospital thoracic surgeon and lung cancer specialist. "If we can slow the penetration of water into the structure, it will slow the release of the drug."
To prevent water from flooding the structure and causing an immediate release of the drug, Grinstaff and his colleagues designed the air-filled, mesh-like material to be "superhydrophobic"so water-resistant that droplets of water barely touch the surface, forming beads similar to those that appear on a freshly waxed car. They produced the porous polymer mesh using a process called electrospinning, which overlays micron-sized fibers upon one another.
To control the rate of drug release, they adjusted chemical and physical properties of the material so that the entrapped air is loosely or tightly held. The more tightly held the air is within the structure, the harder it is for water to displace it, the slower the release, and the longer the treatment duration.
Loaded with a widely used anti-cancer drug called SN-38 in in vitro experiments, the polymer mesh and internal air pocket proved to be robust and effective against lung cancer cells in solution for more than 60 days, indicating its suitability for long-term drug delivery. Grinstaff and his collaborators next plan to conduct a series of in vivo experiments to evaluate the system's efficiency and potential clinical effectivenessa critical preliminary step before initiating clinical trials.
Supported by the National Institutes of Health, The Wallace H. Coulter Foundation, the Center for Integration of Medicine & Innovative Technology and Boston University, this research was originally sparked by the Grinstaff group's ongoing investigation of potential therapies for recurring lung cancer, and interest in the use of new materials and procedures to deliver drugs over the course of months.
"Many researchers are advancing new drug delivery systems, and several others are designing superhydrophobic materials, but we're combining these disciplines to see if we can open up new doors and enable more effective treatments for a wide range of diseases," said Grinstaff.
The researchers detailed their novel drug delivery system in the January 16 online edition of the Journal of the American Chemical Society.
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 31-Jan-2012[ | E-mail |
Share ] Contact: Michael Seele
mseele@bu.edu
617-353-9766
Boston University College of Engineering
BOSTON (1-31-12) -- Long duration, controllable drug delivery is of wide interest to medical researchers and clinicians, particularly those seeking to improve treatment for patients with chronic pain or to prevent cancer recurrence after surgery. Now a team of researchers led by Boston University Biomedical Engineer and Chemist Mark Grinstaff has developed a unique material and drug delivery mechanism that could pave the way for implants that release a drug at a designated rate for months.
The system consists of a biocompatible, highly porous, three-dimensional polymer material containing a selected drug and a volume of air that slows infiltration from surrounding water. As water seeps into the material, it displaces the air, gradually releasing the drug.
"The idea was to create a 3D material that has polymer fibers throughout and air trapped within," said Grinstaff, who developed the material in conjunction with BU biomedical engineering PhD student Stefan Yohe and Dr. Yolanda Colson, a Brigham and Women's Hospital thoracic surgeon and lung cancer specialist. "If we can slow the penetration of water into the structure, it will slow the release of the drug."
To prevent water from flooding the structure and causing an immediate release of the drug, Grinstaff and his colleagues designed the air-filled, mesh-like material to be "superhydrophobic"so water-resistant that droplets of water barely touch the surface, forming beads similar to those that appear on a freshly waxed car. They produced the porous polymer mesh using a process called electrospinning, which overlays micron-sized fibers upon one another.
To control the rate of drug release, they adjusted chemical and physical properties of the material so that the entrapped air is loosely or tightly held. The more tightly held the air is within the structure, the harder it is for water to displace it, the slower the release, and the longer the treatment duration.
Loaded with a widely used anti-cancer drug called SN-38 in in vitro experiments, the polymer mesh and internal air pocket proved to be robust and effective against lung cancer cells in solution for more than 60 days, indicating its suitability for long-term drug delivery. Grinstaff and his collaborators next plan to conduct a series of in vivo experiments to evaluate the system's efficiency and potential clinical effectivenessa critical preliminary step before initiating clinical trials.
Supported by the National Institutes of Health, The Wallace H. Coulter Foundation, the Center for Integration of Medicine & Innovative Technology and Boston University, this research was originally sparked by the Grinstaff group's ongoing investigation of potential therapies for recurring lung cancer, and interest in the use of new materials and procedures to deliver drugs over the course of months.
"Many researchers are advancing new drug delivery systems, and several others are designing superhydrophobic materials, but we're combining these disciplines to see if we can open up new doors and enable more effective treatments for a wide range of diseases," said Grinstaff.
The researchers detailed their novel drug delivery system in the January 16 online edition of the Journal of the American Chemical Society.
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-01/buco-bur013112.php
105.1 alex trebek lightsquared jane lynch matt ryan matt ryan real housewives of new york
You might think of Frequency as a kind of Pandora for video. The app makes it easy to find and watch videos from a variety of sources right on your iPad, but what?s better is that it will create customized channels for you based on your preferences. You can create channels based on your favorite sites, on specific topics and trends, or even just a running list of what your friends are sharing on Facebook and Twitter.
An iOS tie-in to the uber-popular online video game distribution, Steam allows PC gamers the ability to access their accounts on the portal, talk to friends, view games and trailers ? basically everything they can do with the Steam PC app, except for the part about playing video games. But you can still shop for them and purchase them to be digitally downloaded on your computer when you return to it.
Last year, id Software released RAGE HD as an iOS title to go along with its first-person shooter, also titled RAGE. The iOS version contains some slick graphics and great shooter controls, making use of both the touchscreen and the built-in gyroscope to make aiming your weapons feel natural. A ?rail shooter,? RAGE takes care of the movement in the game (it?s as if you were on a rollercoaster), while you do the shooting.
Gamevil?s yearly update to its cartoonish home run-hitting baseball title has gone freemium in Baseball Superstars 2012, but the core of the game will keep fans of the long-running series happy. Like other titles in the Baseball Superstars series, you?ll manage your team and play against others, both computer controlled and online, where you?ll do the pitching and the hitting for your team.
